1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Bivalirudin TFA

Bivalirudin TFA 

Cat. No.: HY-15664 Purity: 99.76%
Handling Instructions

Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bivalirudin TFA Chemical Structure

Bivalirudin TFA Chemical Structure

CAS No. : 1191386-55-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 182 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Bivalirudin TFA:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin. IC50 Value: Target: thrombin in vitro: Eptifibatide (8 mg/mL) added together with a low (70 ng/mL) concentration of bivalirudin (a direct thrombin inhibitor) effectively (approximately 90%) reduced platelet aggregation induced by thrombin (0.2 U/mL) [1]. In thrombin generation assay (TGA), bivalirudin had no effect on these parameters up to 10 μmol/l [2]. Bivalirudin-facilitated binding of MPO to BAEC resulted also in functional changes in terms of increased NO consumption as well as enhanced MPO-mediated redox modifications [3]. in vivo: The use of bivalirudinprevented further increase in antiheparin/PF4 antibody IgG levels in rats [4]. Three animals in the 500-mg/kg/24 h group, and 7 animals in the 2000-mg/kg/24 h group in the toxicokinetic assessment phase of the study were found dead or euthanized in extremis (following blood sampling). Plasma concentrations of bivalirudin appeared to be linear and dose independent [5]. Clinical trial: Antithrombotic Effects of Ticagrelor Versus Clopidogrel . Phase 4

Clinical Trial
Molecular Weight

2295.31

Formula

C₁₀₀H₁₃₈DF₃N₂₄O₃₅

CAS No.

1191386-55-6

Sequence

{d-Phe}-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu

Sequence Shortening

{d-Phe}-PRPGGGGNGDFEEIPEEYL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (43.57 mM; Need ultrasonic)

DMSO : ≥ 31 mg/mL (13.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4357 mL 2.1784 mL 4.3567 mL
5 mM 0.0871 mL 0.4357 mL 0.8713 mL
10 mM 0.0436 mL 0.2178 mL 0.4357 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.76%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

BivalirudinThrombinInhibitorinhibitorinhibit

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Product name:
Bivalirudin TFA
Cat. No.:
HY-15664
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