TRAP-6
Based on 6 publication(s) in Google Scholar
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 141136-83-6
- Formula: C34H56N10O9
- Molecular Weight:748.87
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) TRAP-6
More- Phytomedicine. 2025 Apr 9:141:156736. [Abstract]
- Phytomedicine. 2022 Sep:104:154271. [Abstract]
- J Thromb Haemost. 2025 Mar 26:S1538-7836(25)00200-4. [Abstract]
- J Thromb Haemost. 2024 May;22(5):1463-1474. [Abstract]
- Mol Med Rep. 2019 Jun;19(6):5291-5300. [Abstract]
- Thromb Res. 2024 Feb:234:39-50. [Abstract]
Customer Validation & Images
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ELISA
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IF
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ELISA
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Bio/Physico-chemical Assay
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WB
Biological Activity
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PAR1 96 nM (IC50) |
PAR1 |
TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].
TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141136-83-6
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Appearance Solid
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Molecular Weight 748.87
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Formula C34H56N10O9
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Color White to off-white
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Synonyms
PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6
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Sequence
Ser-Phe-Leu-Leu-Arg-Asn
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Sequence Shortening
SFLLRN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Formononetin attenuates myocardial ischemia/reperfusion injury by regulating neutrophil extracellular traps formation and platelet activation via platelet CD36. [Abstract]2025 Apr 9:141:156736. PMID: 40250000
TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr 9:141:156736. [Abstract]
Trap-6 (25 μM) significantly increased the degree of platelet activation.
TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr 9:141:156736. [Abstract]
Immunofluorescence of platelets and neutrophil extracellular traps (NETs) (MPO, CitH3) (scale bar, 40 μm, n = 3). The results showed that significant NETs formation was observed in both the C+Trap-6 (25 μM) group and the C+Trap-6+FMN+CD36 group. #p < 0.05 vs Sham group; ##p < 0.01 vs Sham group; ###p < 0.001 vs Sham group; *p < 0.05 vs MI/R group, **p < 0.01 vs MI/R group, ***p < 0.001 vs MI/R group; $p < 0.05 vs C+Trap-6+FMN group; $$$p < 0.001 vs C+Trap-6+FMN group.
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Phytomedicine
Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk. [Abstract]2022 Sep:104:154271. PMID: 35777120
TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Sep:104:154271. [Abstract]
Influence of DSS on aggregation of platelets induced by TRAP-6 (2 μM). n = 3.
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J Thromb Haemost
Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface. [Abstract]2025 Mar 26:S1538-7836(25)00200-4. PMID: 40154792
TRAP-6 purchased from MedChemExpress. Usage Cited in: J Thromb Haemost. 2025 Mar 26:S1538-7836(25)00200-4. [Abstract]
To test the effect of LAIR2 on collagen-induced platelet activation, platelets from pregnant women were stimulated with either collagen type I (COL1) or TRAP6, which were either preincubated with or without rhLAIR2 (G). Subsequent aggregometry showed that preincubation with LAIR2 inhibited platelet activation induced by COL1 but not TRAP-6 (50 μM; 30 min)(H).
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J Thromb Haemost
Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity. [Abstract]2024 May;22(5):1463-1474. PMID: 38266680 -
Mol Med Rep
Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways. [Abstract]2019 Jun;19(6):5291-5300. PMID: 31059055
TRAP-6 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Jun;19(6):5291-5300. [Abstract]
Detection of expression levels of p‑AKT, AKT, p‑JNK, JNK and NF‑κB using western blotting. Groups: NC, negative control group; CH, a cholesterol stimulation group; CH+T, cholesterol stimulation with TRAP‑6 treatment group; CH+V, cholesterol stimulation with vorapaxar treatment group.
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Thromb Res
2024 Feb:234:39-50. PMID: 38159323
Solvent & Solubility
H2O : 25 mg/mL (33.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. [Content Brief]
[2]. Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6. [Content Brief]
[3]. Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349(2-3):237-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.3353 mL | 6.6767 mL | 13.3535 mL | 33.3836 mL |
| 5 mM | 0.2671 mL | 1.3353 mL | 2.6707 mL | 6.6767 mL | |
| 10 mM | 0.1335 mL | 0.6677 mL | 1.3353 mL | 3.3384 mL | |
| 15 mM | 0.0890 mL | 0.4451 mL | 0.8902 mL | 2.2256 mL | |
| 20 mM | 0.0668 mL | 0.3338 mL | 0.6677 mL | 1.6692 mL | |
| 25 mM | 0.0534 mL | 0.2671 mL | 0.5341 mL | 1.3353 mL | |
| 30 mM | 0.0445 mL | 0.2226 mL | 0.4451 mL | 1.1128 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TRAP-6 Related Classifications
Cat. No.: HY-P0078
Powered by Bioz
- TRAP-6
- 141136-83-6
- PAR-1 agonist peptide
- Thrombin Receptor Activator Peptide 6
- TRAP6
- TRAP 6
- Thrombin Receptor Activator Peptide6
- Thrombin Receptor Activator Peptide 6
- Thrombin Receptor Activator Peptide-6
- Protease Activated Receptor (PAR)
- protease
- activating
- receptor
- PAR1
- platelets
- thrombin
- Inhibitor
- inhibitor
- inhibit