1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Argatroban monohydrate

Argatroban monohydrate (Synonyms: MD-805 (monohydrate); MCI-9038 (monohydrate); Argipidine (monohydrate))

Cat. No.: HY-B0375A Purity: 99.95%
Handling Instructions

Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.

For research use only. We do not sell to patients.

Argatroban monohydrate Chemical Structure

Argatroban monohydrate Chemical Structure

CAS No. : 141396-28-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 190 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Argatroban monohydrate:

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Description

Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.

IC50 & Target

Thrombin[1].

In Vitro

Argatroban (MD-805) may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of Argatroban (MD-805) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries[1]. Argatroban (MD-805), as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban[2].

Clinical Trial
Molecular Weight

526.65

Formula

C₂₃H₃₈N₆O₆S

CAS No.

141396-28-3

SMILES

O=C([[email protected]@H]1N(C([[email protected]@H](NS(=O)(C2=CC=CC3=C2NCC(C)C3)=O)CCCNC(N)=N)=O)CC[[email protected]@H](C)C1)O.O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (189.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8988 mL 9.4940 mL 18.9879 mL
5 mM 0.3798 mL 1.8988 mL 3.7976 mL
10 mM 0.1899 mL 0.9494 mL 1.8988 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Argatroban monohydrate
Cat. No.:
HY-B0375A
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