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Tranexamic acid  (Synonyms: cyclocapron)

Cat. No.: HY-B0149 Purity: ≥98.0%
COA Handling Instructions

Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

For research use only. We do not sell to patients.

Tranexamic acid Chemical Structure

Tranexamic acid Chemical Structure

CAS No. : 1197-18-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 33 In-stock
Solution
10 mM * 1 mL in Water USD 33 In-stock
Solid
500 mg USD 30 In-stock
5 g USD 60 In-stock
10 g USD 84 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tranexamic acid:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tranexamic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis [1][2][3][4][5].

IC50 & Target

MMP-1

 

In Vitro

Tranexamic acid (20-100 μg/mL, 24 h) attenuates the effects of severe trauma by enhancing mitochondrial respiration, suppressing damage-associated molecular patterns (DAMPs) release and improving capillary integrity in human umbilical vein endothelial cells (HUVECs) and human arterial endothelial cells (HAECs)[1].
Tranexamic acid (0.2-5 mM, 30 min) inhibits cell migration of MDA-MB-231 BAG breast cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [2]

Cell Line: MDA-MB-231
Concentration: 0.2 mM, 1 mM, 5mM
Incubation Time: 30 min
Result: Significantly inhibits cell migration with the inhibition of 26% ± 8.4% at 0.2 mM and 40% ± 4.2% at 1 mM.
In Vivo

Tranexamic acid (100 mg/kg, Intravenous injection, twice a day for 3-28 days) facilitates a more robust immune activation after traumatic brain injury in plasminogen-deficient mice[3].
Tranexamic acid (750 mg/kg, Oral, once a day for 20 consecutive days) decreases the proliferation of mast cells and increases the proliferation of fibroblasts, subsequently improving wrinkles caused by skin dryness in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Traumatic brain injury (TBI) mice[3]
Dosage: 100 mg/kg
Administration: Intravenous injection (i.v.)
Result: Inhibited local plasmin formation and fibrinolysis.
Impacts on the local immune response following TBI.
Did not enhance reactivity of cervical lymph node (cLN) cells to central nervous system (CNS) antigens.
Influences the cellular immune profile of peripheral lymph nodes.
Reduced microglial and macrophage activation.
Animal Model: Skin dryness induced wrinkles mice[4]
Dosage: 750 mg/kg
Administration: Oral
Result: Resulted in the amelioration of transepidermal water loss (TEWL) and moisture retention.
Suppressed the generation of wrinkles.
Inhibited plasma concentrations of adrenocorticotropic hormone (ACTH), corticosterone, and IgE.
Suppressed proliferation of mast cells.
Clinical Trial
Molecular Weight

157.21

Formula

C8H15NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1CC[C@H](CN)CC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (318.05 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3609 mL 31.8046 mL 63.6092 mL
5 mM 1.2722 mL 6.3609 mL 12.7218 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (636.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.3609 mL 31.8046 mL 63.6092 mL 159.0230 mL
5 mM 1.2722 mL 6.3609 mL 12.7218 mL 31.8046 mL
10 mM 0.6361 mL 3.1805 mL 6.3609 mL 15.9023 mL
15 mM 0.4241 mL 2.1203 mL 4.2406 mL 10.6015 mL
20 mM 0.3180 mL 1.5902 mL 3.1805 mL 7.9511 mL
25 mM 0.2544 mL 1.2722 mL 2.5444 mL 6.3609 mL
30 mM 0.2120 mL 1.0602 mL 2.1203 mL 5.3008 mL
40 mM 0.1590 mL 0.7951 mL 1.5902 mL 3.9756 mL
50 mM 0.1272 mL 0.6361 mL 1.2722 mL 3.1805 mL
60 mM 0.1060 mL 0.5301 mL 1.0602 mL 2.6504 mL
80 mM 0.0795 mL 0.3976 mL 0.7951 mL 1.9878 mL
100 mM 0.0636 mL 0.3180 mL 0.6361 mL 1.5902 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tranexamic acid
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