APC-6860
APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 154628-42-9
- 分子式: C9H7IN2S
- 分子量:302.13
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
uPA 0.21 μM (Ki) |
trypsin 0.44 μM (Ki) |
tryptase 1.5 μM (Ki) |
tPA 16.8 μM (Ki) |
thrombin 20 μM (Ki) |
factor Xa 30 μM (Ki) |
human urokinases 0.1 μM (Ki) |
murine urokinases 0.082 μM (Ki) |
APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 154628-42-9
-
分子量 302.13
-
分子式 C9H7IN2S
-
SMILES
N=C(C1=CC2=C(I)C=CC=C2S1)N
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [Content Brief]
[2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001 Aug 7;40(31):9125-31. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
APC-6860 関連分類
HY-114015 関連分類
Powered by Bioz