1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. APC-6860

APC-6860 

Cat. No.: HY-114015
Handling Instructions

APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.

For research use only. We do not sell to patients.

APC-6860 Chemical Structure

APC-6860 Chemical Structure

CAS No. : 154628-42-9

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Description

APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2].

IC50 & Target[1][2]

uPA

0.21 μM (Ki)

trypsin

0.44 μM (Ki)

tryptase

1.5 μM (Ki)

tPA

16.8 μM (Ki)

thrombin

20 μM (Ki)

factor Xa

30 μM (Ki)

human urokinases

0.1 μM (Ki)

murine urokinases

0.082 μM (Ki)

In Vitro

APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.13

Formula

C9H7IN2S

CAS No.
SMILES

N=C(C1=CC2=C(I)C=CC=C2S1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
APC-6860
Cat. No.:
HY-114015
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