154628-42-9
154628-42-9
Chemical Structure
APC-6860
- CAS No.: 154628-42-9
- Formula:C9H7IN2S
- Molecular Weight:302.13
IUPAC Name: 4-iodobenzo[b]thiophene-2-carboximidamide
InChIKey: YERQOXAYAFWFEJ-UHFFFAOYSA-N
SMILES: N=C(C1=CC2=C(I)C=CC=C2S1)N
Biological Activity: APC-6860 is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 is applicable to research related to breast cancer and prostate cancer[1][2].
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APC-6860 | APC-6860 is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 is applicable to research related to breast cancer and prostate cancer. | |||||||||||||||||||||
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References
- [1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [Content Brief]
- [2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001;40(31):9125-9131. [Content Brief]
