Rovunaptabin  (Synonyms: ARC 183; BC 007)

Rovunaptabin (ARC 183) is an aptamer, a single-stranded DNA molecule composed of 15 deoxynucleotides. It acts as a broad-spectrum neutralizer of pathogenic G-protein-coupled receptor autoantibodies. Rovunaptabin can be used in research related to cardiomyopathy and pulmonary hypertension^[1][2].

Rovunaptabin (100 nM; 1 h) shows species-specific neutralization in spontaneously beating neonatal rat cardiomyocytes, fully neutralizing rat and rabbit G-protein-coupled receptor autoantibodies, partially neutralizing goat autoantibodies, and failing to neutralize chicken autoantibodies^[1].
Rovunaptabin (100 nM) binds to the Fab region of human ETA-receptor and beta1-adrenoceptor autoantibodies, preventing restoration of agonistic activity via cross-linking in spontaneously beating neonatal rat cardiomyocytes^[1].
Rovunaptabin (1 μM) forms a detectable complex with 1.5 μM human beta1-adrenoceptor autoantibodies in an electrophoretic mobility shift assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rovunaptabin efficiently neutralizes beta1-adrenoceptor autoantibodies in vivo in spontaneously hypertensive rats and clears both beta1-adrenoceptor and muscarinic M2-receptor autoantibodies from rat serum^[1].
Treatment with Rovunaptabin (BC 007) (1-4 mg/kg; i.v. infusion over 20 min; single dose; second single dose (9 months after initial)) safely neutralizes β₁-adrenergic receptor autoantibodies in β₁-AAB-positive Doberman Pinschers with dilated cardiomyopathy, reduces or stabilizes left ventricular volumes during β₁-AAB-free periods, and significantly prolongs median cardiac survival to 572 days^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4726.07

145563-68-4

Solid

White to off-white

DNA, d(G-G-T-T-G-G-T-G-T-G-G-T-T-G-G)

DNA, d(G-G-T-T-G-G-T-G-T-G-G-T-T-G-G)

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Haberland A, et al. Aptamer BC 007 - A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors. Eur J Pharmacol. 2016;789:37-45.  [Content Brief]

  [2]. Werner S, et al. The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes. ESC Heart Fail. 2020;7(3):844-855.  [Content Brief]