2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Protease-Activated Receptor-1, PAR-1 Agonist

Protease-Activated Receptor-1, PAR-1 Agonist 

Cat. No.: HY-P2518 Purity: 98.34%
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Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.

For research use only. We do not sell to patients.

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Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure

Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure

CAS No. : 141136-85-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Protease-Activated Receptor-1, PAR-1 Agonist:

Protease-Activated Receptor-1, PAR-1 Agonist Related Antibodies

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Description

Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].

IC50 & Target

PAR-1[1]
In Vitro

Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Gö 6976[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Protease-Activated Receptor-1, PAR-1 Agonist Related Antibodies
Molecular Weight

762.90

Formula

C35H58N10O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Thr-Phe-Leu-Leu-Arg-Asn
Sequence Shortening

TFLLRN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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Protease-Activated Receptor-1, PAR-1 Agonist Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protease-Activated Receptor-1, PAR-1 Agonist141136-85-8Protease Activated Receptor (PAR)Thrombin receptorsprotease-activatedreceptorPAR-1thrombinInhibitorinhibitorinhibit

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