1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. I-191

I-191 

Cat. No.: HY-117793 Purity: 98.02%
Handling Instructions

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist.

For research use only. We do not sell to patients.

I-191 Chemical Structure

I-191 Chemical Structure

CAS No. : 1690172-25-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

IC50 & Target

Protease-activated receptor 2[1]

In Vitro

I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1].

Molecular Weight

423.48

Formula

C₂₃H₂₆FN₅O₂

CAS No.

1690172-25-8

SMILES

O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3614 mL 11.8069 mL 23.6139 mL
5 mM 0.4723 mL 2.3614 mL 4.7228 mL
10 mM 0.2361 mL 1.1807 mL 2.3614 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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I-191
Cat. No.:
HY-117793
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