1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. I-191

I-191 

Cat. No.: HY-117793
Handling Instructions

I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively.

For research use only. We do not sell to patients.

I-191 Chemical Structure

I-191 Chemical Structure

CAS No. : 1690172-25-8

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Description

I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively[1].

IC50 & Target

IC50: 0.0014 μM (SLIGKV), 0.0023 μM (Trypsin), 0.32 μM (Thrombin)[1]

References
Molecular Weight

423.48

Formula

C₂₃H₂₆FN₅O₂

CAS No.

1690172-25-8

SMILES

O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
I-191
Cat. No.:
HY-117793
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I-191

Cat. No.: HY-117793