1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. AC-264613

AC-264613 

Cat. No.: HY-14351
Handling Instructions

AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5.

For research use only. We do not sell to patients.

AC-264613 Chemical Structure

AC-264613 Chemical Structure

CAS No. : 1051487-82-1

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Description

AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1].

IC50 & Target

pEC50: 7.5 (PAR-2)[1]

In Vitro

AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages[2].

Western Blot Analysis[2]

Cell Line: Granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophages
Concentration: 10 μM
Incubation Time: 6 hours
Result: Significantly decreased IRF5 expression and reduced p53 protein levels.
In Vivo

AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats[3].

Molecular Weight

400.27

Formula

C₁₉H₁₈BrN₃O₂

CAS No.

1051487-82-1

SMILES

O=C(N/N=C(C1=CC=CC(Br)=C1)\C)[[email protected]]2[[email protected]@H](CNC2=O)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AC-264613AC264613AC 264613Protease-Activated Receptor (PAR)Thrombin receptorsIRF5macrophageinflammatoryrheumatoidarthritisInhibitorinhibitorinhibit

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AC-264613
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