PAR-4 Agonist Peptide, amide
Based on 2 publication(s) in Google Scholar
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 352017-71-1
- Formula: C34H48N8O7
- Molecular Weight:680.79
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PAR-4 Agonist Peptide, amide
More
Biological Activity
PAR-4[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 352017-71-1
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Appearance Solid
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Molecular Weight 680.79
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Formula C34H48N8O7
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Color White to off-white
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Synonyms
PAR-4-AP; AY-NH2
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Sequence
Ala-Tyr-Pro-Gly-Lys-Phe-NH2
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Sequence Shortening
AYPGKF-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Immunity
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia. [Abstract]2022 Feb 8;55(2):224-236.e5. PMID: 34995475 -
Mol Nutr Food Res
A Collagen-Derived Oligopeptide from Salmo salar Collagen Hydrolysates Restrains Atherogenesis in ApoE-/- Mice via Targeting P2 Y12 Receptor. [Abstract]2022 Jul;66(13):e2200166. PMID: 35490399
Solvent & Solubility
DMSO : 100 mg/mL (146.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (146.89 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Mice[1]
SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.4689 mL | 7.3444 mL | 14.6888 mL | 36.7220 mL |
| 5 mM | 0.2938 mL | 1.4689 mL | 2.9378 mL | 7.3444 mL | |
| 10 mM | 0.1469 mL | 0.7344 mL | 1.4689 mL | 3.6722 mL | |
| 15 mM | 0.0979 mL | 0.4896 mL | 0.9793 mL | 2.4481 mL | |
| 20 mM | 0.0734 mL | 0.3672 mL | 0.7344 mL | 1.8361 mL | |
| 25 mM | 0.0588 mL | 0.2938 mL | 0.5876 mL | 1.4689 mL | |
| 30 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2241 mL | |
| 40 mM | 0.0367 mL | 0.1836 mL | 0.3672 mL | 0.9181 mL | |
| 50 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7344 mL | |
| 60 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6120 mL | |
| 80 mM | 0.0184 mL | 0.0918 mL | 0.1836 mL | 0.4590 mL | |
| 100 mM | 0.0147 mL | 0.0734 mL | 0.1469 mL | 0.3672 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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