1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. PAR-4 Agonist Peptide, amide TFA

PAR-4 Agonist Peptide, amide TFA (Synonyms: PAR-4-AP (TFA); AY-NH2 (TFA))

Cat. No.: HY-P1309A Purity: 99.93%
Handling Instructions

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PAR-4 Agonist Peptide, amide TFA Chemical Structure

PAR-4 Agonist Peptide, amide TFA Chemical Structure

CAS No. : 1228078-65-6

Size Price Stock Quantity
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 530 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1].

IC50 & Target

PAR-4[1]

In Vivo

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].

Molecular Weight

794.82

Formula

C₃₆H₄₉F₃N₈O₉

CAS No.

1228078-65-6

Sequence

Ala-Tyr-Pro-Gly-Lys-Phe-NH2

Sequence Shortening

AYPGKF-NH2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (314.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2581 mL 6.2907 mL 12.5815 mL
5 mM 0.2516 mL 1.2581 mL 2.5163 mL
10 mM 0.1258 mL 0.6291 mL 1.2581 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice[1]
SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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PAR-4 Agonist Peptide, amide TFA
Cat. No.:
HY-P1309A
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