1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. Protease-Activated Receptor-1, PAR-1 Agonist TFA

Protease-Activated Receptor-1, PAR-1 Agonist TFA 

Cat. No.: HY-P2518A Purity: 99.08%
Handling Instructions

Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Protease-Activated Receptor-1, PAR-1 Agonist TFA Chemical Structure

Protease-Activated Receptor-1, PAR-1 Agonist TFA Chemical Structure

Size Price Stock Quantity
10 mg USD 425 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].

In Vitro

Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Gö 6976[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

876.92

Formula

C₃₇H₅₉F₃N₁₀O₁₁

Sequence

Thr-Phe-Leu-Leu-Arg-Asn

Sequence Shortening

TFLLRN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (7.61 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1404 mL 5.7018 mL 11.4035 mL
5 mM 0.2281 mL 1.1404 mL 2.2807 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Protease-Activated Receptor-1, PAR-1 Agonist TFA
Cat. No.:
HY-P2518A
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