1. GPCR/G Protein
  2. Protease Activated Receptor (PAR)
  3. AZ3451

AZ3451 

Cat. No.: HY-112558 Purity: 99.60%
COA Handling Instructions

AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.

For research use only. We do not sell to patients.

AZ3451 Chemical Structure

AZ3451 Chemical Structure

CAS No. : 2100284-59-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 97 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 97 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
25 mg USD 297 In-stock
Estimated Time of Arrival: December 31
50 mg USD 517 In-stock
Estimated Time of Arrival: December 31
100 mg USD 902 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.

IC50 & Target

Protease-activated receptor-2 (IC50= 23 nM)[1]

In Vitro

Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

571.46

Formula

C30H27BrN4O3

CAS No.
SMILES

O=C(C1=CC=C2C(N=C(C3=C(Br)C=C(OCO4)C4=C3)N2[[email protected]](C5CCCCC5)C)=C1)NC6=CC=C(C#N)C=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7499 mL 8.7495 mL 17.4990 mL
5 mM 0.3500 mL 1.7499 mL 3.4998 mL
10 mM 0.1750 mL 0.8750 mL 1.7499 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.60%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
AZ3451
Cat. No.:
HY-112558
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