1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. AZ3451

AZ3451 

Cat. No.: HY-112558 Purity: 99.33%
Handling Instructions

AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.

For research use only. We do not sell to patients.

AZ3451 Chemical Structure

AZ3451 Chemical Structure

CAS No. : 2100284-59-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 270 In-stock
Estimated Time of Arrival: December 31
50 mg USD 470 In-stock
Estimated Time of Arrival: December 31
100 mg USD 820 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.

IC50 & Target

Protease-activated receptor-2 (IC50= 23 nM)[1]

In Vitro

Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling[1].

Molecular Weight

571.46

Formula

C₃₀H₂₇BrN₄O₃

CAS No.

2100284-59-9

SMILES

O=C(C1=CC=C2C(N=C(C3=C(Br)C=C(OCO4)C4=C3)N2[[email protected]](C5CCCCC5)C)=C1)NC6=CC=C(C#N)C=C6

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (145.77 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7499 mL 8.7495 mL 17.4990 mL
5 mM 0.3500 mL 1.7499 mL 3.4998 mL
10 mM 0.1750 mL 0.8750 mL 1.7499 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.33%

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AZ3451
Cat. No.:
HY-112558
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