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  4. H-D-Phe-Pip-Arg-pNA

H-D-Phe-Pip-Arg-pNA  (Synonyms: S-2238)

Cat. No.: HY-123275 Purity: 95.98%
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H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

H-D-Phe-Pip-Arg-pNA

H-D-Phe-Pip-Arg-pNA Chemical Structure

CAS No. : 64815-81-2

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Based on 1 publication(s) in Google Scholar

Other Forms of H-D-Phe-Pip-Arg-pNA:

H-D-Phe-Pip-Arg-pNA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE H-D-Phe-Pip-Arg-pNA

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Description

H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2].

Molecular Weight

552.63

Formula

C27H36N8O5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

{D-Phe}-{Pip}-R-pNA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (45.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8095 mL 9.0476 mL 18.0953 mL
5 mM 0.3619 mL 1.8095 mL 3.6191 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8095 mL 9.0476 mL 18.0953 mL 45.2382 mL
5 mM 0.3619 mL 1.8095 mL 3.6191 mL 9.0476 mL
10 mM 0.1810 mL 0.9048 mL 1.8095 mL 4.5238 mL
15 mM 0.1206 mL 0.6032 mL 1.2064 mL 3.0159 mL
20 mM 0.0905 mL 0.4524 mL 0.9048 mL 2.2619 mL
25 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
30 mM 0.0603 mL 0.3016 mL 0.6032 mL 1.5079 mL
40 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1310 mL
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H-D-Phe-Pip-Arg-pNA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-D-Phe-Pip-Arg-pNA64815-81-2S-2238S2238S 2238Fluorescent Dyechromogenicsubstratefibrinogenthrombinantithrombin-heparincofactorAT-IIIInhibitorinhibitorinhibit

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