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H-D-Phe-Pip-Arg-pNA hydrochloride  (Synonyms: S-2238 hydrochloride)

Cat. No.: HY-123275A Purity: 99.35%
COA Handling Instructions

H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

H-D-Phe-Pip-Arg-pNA hydrochloride Chemical Structure

H-D-Phe-Pip-Arg-pNA hydrochloride Chemical Structure

CAS No. : 160192-34-7

Size Price Stock Quantity
1 mg USD 80 In-stock
5 mg USD 240 In-stock
10 mg USD 380 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2].

Molecular Weight

589.09

Formula

C27H37ClN8O5

CAS No.
Appearance

Solid

Color

Light yellow to yellow

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (424.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6975 mL 8.4877 mL 16.9753 mL
5 mM 0.3395 mL 1.6975 mL 3.3951 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6975 mL 8.4877 mL 16.9753 mL 42.4383 mL
5 mM 0.3395 mL 1.6975 mL 3.3951 mL 8.4877 mL
10 mM 0.1698 mL 0.8488 mL 1.6975 mL 4.2438 mL
15 mM 0.1132 mL 0.5658 mL 1.1317 mL 2.8292 mL
20 mM 0.0849 mL 0.4244 mL 0.8488 mL 2.1219 mL
25 mM 0.0679 mL 0.3395 mL 0.6790 mL 1.6975 mL
30 mM 0.0566 mL 0.2829 mL 0.5658 mL 1.4146 mL
40 mM 0.0424 mL 0.2122 mL 0.4244 mL 1.0610 mL
50 mM 0.0340 mL 0.1698 mL 0.3395 mL 0.8488 mL
60 mM 0.0283 mL 0.1415 mL 0.2829 mL 0.7073 mL
80 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5305 mL
100 mM 0.0170 mL 0.0849 mL 0.1698 mL 0.4244 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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H-D-Phe-Pip-Arg-pNA hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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H-D-Phe-Pip-Arg-pNA hydrochloride
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