2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Ciraparantag

Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.

For research use only. We do not sell to patients.

Ciraparantag Chemical Structure

Ciraparantag Chemical Structure

CAS No. : 1438492-26-2

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Solid + Solvent
10 mM * 1 mL in Water
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Ciraparantag Related Antibodies

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Description

Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban[1][2][3][4].

IC50 & Target

thrombin, factor Xa[1]
In Vitro

Ciraparantag is a small-molecule antidote for unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), and certain direct oral anticoagulants (DOACs)[2].
Ciraparantag is a small synthetic and cationic molecule that binds direct Xa inhibitors, direct thrombin inhibitors, and unfractionated and low molecular weight heparin (LMWH) through non-covalent hydrogen bonds and charge–charge interactions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ciraparantag Related Antibodies
Molecular Weight

512.70

Formula

C22H48N12O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCN1CCN(CCCNC([C@@H](N)CCCNC(N)=N)=O)CC1)[C@@H](N)CCCNC(N)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 31 mg/mL (60.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9505 mL 9.7523 mL 19.5046 mL
5 mM 0.3901 mL 1.9505 mL 3.9009 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9505 mL 9.7523 mL 19.5046 mL 48.7615 mL
5 mM 0.3901 mL 1.9505 mL 3.9009 mL 9.7523 mL
10 mM 0.1950 mL 0.9752 mL 1.9505 mL 4.8761 mL
15 mM 0.1300 mL 0.6502 mL 1.3003 mL 3.2508 mL
20 mM 0.0975 mL 0.4876 mL 0.9752 mL 2.4381 mL
25 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9505 mL
30 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6254 mL
40 mM 0.0488 mL 0.2438 mL 0.4876 mL 1.2190 mL
50 mM 0.0390 mL 0.1950 mL 0.3901 mL 0.9752 mL
60 mM 0.0325 mL 0.1625 mL 0.3251 mL 0.8127 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ciraparantag Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ciraparantag1438492-26-2PER977PER 977PER-977Factor XaFxathrombin,factor,Xa,UFH,LMWH,DOACInhibitorinhibitorinhibit

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