1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Dabigatran etexilate mesylate

Dabigatran etexilate mesylate (Synonyms: BIBR 1048MS; Dabigatran etexilate methanesulfonate)

Cat. No.: HY-10274A Purity: 99.93%
Handling Instructions

Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.

For research use only. We do not sell to patients.

Dabigatran etexilate mesylate Chemical Structure

Dabigatran etexilate mesylate Chemical Structure

CAS No. : 872728-81-9

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Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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5 mg USD 48 In-stock
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10 mg USD 67 In-stock
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50 mg USD 86 In-stock
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100 mg USD 115 In-stock
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200 mg USD 173 In-stock
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500 mg USD 250 In-stock
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1 g USD 346 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].

In Vivo

Dabigatran etexilate mesylate (BIBR 1048MS; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively[1].
Dabigatran etexilate mesylate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively[1].
Dabigatran etexilate mesylate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats (280-350 g) and rhesus monkeys of either sex (3-8 kg)[1]
Dosage: 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys
Administration: Oral
Result: Had dose- and time-dependent anticoagulant effects.
Clinical Trial
Molecular Weight

723.84

Formula

C35H45N7O8S

CAS No.
SMILES

O=C(N(C1=NC=CC=C1)CCC(OCC)=O)C2=CC=C3C(N=C(N3C)CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4)=C2.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (34.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3815 mL 6.9076 mL 13.8152 mL
5 mM 0.2763 mL 1.3815 mL 2.7630 mL
10 mM 0.1382 mL 0.6908 mL 1.3815 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.93%

References
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Product Name:
Dabigatran etexilate mesylate
Cat. No.:
HY-10274A
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