1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. UK122

UK122 

Cat. No.: HY-111056
Handling Instructions

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion.

For research use only. We do not sell to patients.

UK122 Chemical Structure

UK122 Chemical Structure

CAS No. : 940290-58-4

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Description

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].

In Vitro

UK122 (11.1, 33.3, 100 μM; 24 h) dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1].
UK122 (10-100 μM; 48 h) has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

291.30

Formula

C₁₇H₁₃N₃O₂

CAS No.
SMILES

N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UK122UK 122UK-122Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesurokinase-typeplasminogenuPAtPAplasminthrombintrypsinmigratioinvasionCFPAC-1pancreaticInhibitorinhibitorinhibit

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