UK122 hydrochloride

Cat. No.: HY-111056A Purity: 99.43%: Data Sheet
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UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC₅₀ of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion.

For research use only. We do not sell to patients.

UK122 hydrochloride Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of UK122 hydrochloride:

UK122 TFA In-stock
(E)-UK122 TFA Get quote

1 Publications Citing Use of MCE UK122 hydrochloride

•bioRxiv. 2025 Jun 17:2025.06.11.659108. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description	UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC₅₀ of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion^[1].
In Vitro	UK122 (11.1-100 μM; 24 h) hydrochloride dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells^[1]. UK122 (10-100 μM; 48 h) hydrochloride has no effect of any cell growth or cell morphology change in CFPAC-1 cells^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. UK122 hydrochloride Related Antibodies
Molecular Weight	327.76
Formula	C₁₇H₁₄ClN₃O₂
Appearance	Solid
Color	Light yellow to yellow
SMILES	N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 99.43% Select Batch: Data Sheet (269 KB) SDS (251 KB) COA (248 KB) HNMR (266 KB) RP-HPLC (238 KB) MS (69 KB) Handling Instructions (2659 KB)
References	[1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56. [Content Brief]