1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. Patamostat mesylate

Patamostat mesylate (Synonyms: E-3123 mesylate)

Cat. No.: HY-114080A
Handling Instructions

Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.

For research use only. We do not sell to patients.

Patamostat mesylate Chemical Structure

Patamostat mesylate Chemical Structure

CAS No. : 114568-32-0

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Description

Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].

IC50 & Target

IC50: 39 nM (trypsin), 950 nM (plasmin) and 1.9 μM (thrombin)[1]

In Vivo

Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].
Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1].
Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing about 350 g[2]
Dosage: 2 mg/kg
Administration: Continuous infusion per h for 1 h
Result: Significantly improved the survival rate.
Molecular Weight

508.57

Formula

C₂₁H₂₄N₄O₇S₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Patamostat mesylate
Cat. No.:
HY-114080A
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