114568-32-0
Chemical Structure
Patamostat mesylate
Synonym(s): E-3123 mesylate
- CAS No.: 114568-32-0
- Formula:C21H24N4O7S2
- Molecular Weight:508.57
IUPAC Name: 4-((2-(2,5-dioxopyrrolidin-1-yl)ethyl)thio)phenyl 4-guanidinobenzoate methanesulfonate
InChIKey: HTSFLDCSCNSKJW-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=C(SCCN2C(CCC2=O)=O)C=C1)C3=CC=C(NC(N)=N)C=C3.CS(O)(=O)=O
Biological Activity: Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].
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Patamostat mesylate | Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis. | |||||||||||||||||||||
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- [1]. K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93. [Content Brief]
- [2]. T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. [Content Brief]
Keywords
