Napsagatran hydrate
Napsagatran (Ro 46-6240) hydrate is a potent thrombin inhibitor. Napsagatran hydrate exhibits anticoagulant effects in vitro and in vivo. Napsagatran hydrate can be used in antithrombotic research[1][2].
For research use only. We do not sell to patients.
- CAS No.: 159668-20-9
- Formula: C26H36N6O7S
- Molecular Weight:576.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Napsagatran (10 μg/kg/min) hydrate reduces platelet-rich thrombus formation in an ex vivo perfusion chamber model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Napsagatran (10 μg/kg/min, i.v., infusion for 240 minutes) hydrate significantly reduces thrombus associated fibrin in rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand rabbits[2]
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Dosage:10 μg/kg/min
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Administration:i.v., infusion for 240 minutes
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Result:Showed a 1.3-fold prolongation of the prothrombin time (PT) and a 1.7-fold prolongation of the partial thromboplastin time (APTT).
Significantly reduced thrombus associated fibrin after 240 min blood flow exposure.
Showed no effects in heart rate, blood pressure, plasma fibrinogen concentrations, hematocrit and blood cell counts over time.
Chemical Information
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CAS No. 159668-20-9
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Molecular Weight 576.67
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Formula C26H36N6O7S
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SMILES
O=C(NC[C@H]1CN(C(N)=N)CCC1)C[C@@H](C(N(C2CC2)CC(O)=O)=O)NS(C3=CC4=CC=CC=C4C=C3)(=O)=O.O
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Synonyms
Ro 46-6240 hydrate; Ro 46-6240/010 hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Roux S, et al. Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther. 1996 Apr;277(1):71-8. [Content Brief]
[2]. Himber J, et al. Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost. 2003 May;1(5):889-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Napsagatran hydrate Related Classifications
HY-15759A Related Classifications
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