1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Trequinsin hydrochloride

Trequinsin hydrochloride (Synonyms: HL 725)

Cat. No.: HY-18740A Purity: 99.96%
Handling Instructions

Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC50 of 0.25 nM. Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin and epinephrine.

For research use only. We do not sell to patients.

Trequinsin hydrochloride Chemical Structure

Trequinsin hydrochloride Chemical Structure

CAS No. : 78416-81-6

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Description

Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC50 of 0.25 nM. Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin and epinephrine[1][2][3].

In Vitro

Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities[1].
Trequinsin hydrochloride is an efficacious agonist of [Ca2+]i[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria.
Concentration: 10 μM.
Incubation Time: 20 min.
Result: Caused a concentrationdependent increase in [Ca2+]i (EC50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]).
Molecular Weight

441.95

Formula

C₂₄H₂₈ClN₃O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (141.42 mM; Need ultrasonic)

H2O : 50 mg/mL (113.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2627 mL 11.3135 mL 22.6270 mL
5 mM 0.4525 mL 2.2627 mL 4.5254 mL
10 mM 0.2263 mL 1.1313 mL 2.2627 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Trequinsin hydrochloride
Cat. No.:
HY-18740A
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