Trequinsin

Trequinsin (40 μM; 82 min) induces a high-magnitude increase in intracellular calcium in pooled capacitated human donor sperm, equivalent to 91% of the response evoked by 10 μM Progesterone (HY-N0437)^[1].
Trequinsin (0.1-30 μM) induces a concentration-dependent increase in intracellular calcium in capacitated human donor sperm with an EC₅₀ of 3.43 μM, exhibits efficacy equivalent to progesterone at 10 μM, and cross-desensitises with PGE₁ but not progesterone^[1].
Trequinsin (10 μM; 120 min) significantly and sustainably increases hyperactivated motility in capacitated human donor sperm (80% density gradient centrifugation fraction) without altering total or progressive motility^[1].
Trequinsin (10 μM; 120 min) significantly increases progressive motility in poor-motility human donor sperm (40% density gradient centrifugation fraction) under both capacitating and non-capacitating conditions, and increases hyperactivated motility under capacitating conditions^[1].
Trequinsin (10 μM; 120 min) increases hyperactivated motility in the majority of capacitated human patient sperm samples, with no effect on total or progressive motility in most cases^[1].
Trequinsin (10 μM; 20 min) does not induce premature acrosome reaction in capacitated human donor sperm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.