1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Sfllrnpndkyepf


Cat. No.: HY-P1000 Purity: 98.22%
Handling Instructions

SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.

For research use only. We do not sell to patients.

Sfllrnpndkyepf Chemical Structure

Sfllrnpndkyepf Chemical Structure

CAS No. : 137339-65-2

Size Price Stock Quantity
10 mM * 1 mL in Water USD 1470 In-stock
Estimated Time of Arrival: December 31
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 432 In-stock
Estimated Time of Arrival: December 31
10 mg USD 768 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.

In Vitro

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. SFLLRNPNDKYEPF, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. SFLLRNPNDKYEPF, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. SFLLRNPNDKYEPF is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3].

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Molecular Weight









Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-P1000