1. Metabolic Enzyme/Protease
  2. Thrombin

Sfllrnpndkyepf (Synonyms: Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe; SFLLRNPNDKYEPF)

Cat. No.: HY-P1000
Handling Instructions

SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.

For research use only. We do not sell to patients.
Sfllrnpndkyepf Chemical Structure

Sfllrnpndkyepf Chemical Structure

CAS No. : 137339-65-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1470 In-stock
1 mg USD 108 In-stock
5 mg USD 432 In-stock
10 mg USD 768 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References


SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.

In Vitro

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. SFLLRNPNDKYEPF, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. SFLLRNPNDKYEPF, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. SFLLRNPNDKYEPF is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3].

Molecular Weight







CC(C[[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](N)([H])CO)([H])CC1=CC=CC=C1)([H])CC(C)C)([H])/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](C(N2CCC[[email protected]@]2([H])/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](C(N3CCC[[email protected]@]3([H])/C(O)=N/[[email protected]@](C(O)=O)([H])CC4=CC=CC=C4)=O)([H])CCC(O)=O)([H])CC5=CC=C(O)C=C5)([H])CCCCN)([H])CC(O)=O)([H])CC(O)=N)=O)([H])CC(O)=N)([H])CCCNC(N)=N)C


Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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