1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Sfllrnpndkyepf

Sfllrnpndkyepf 

Cat. No.: HY-P1000 Purity: 98.22%
Handling Instructions

Sfllrnpndkyepf is a synthetic thrombin receptor agonist peptide.

For research use only. We do not sell to patients.

Sfllrnpndkyepf Chemical Structure

Sfllrnpndkyepf Chemical Structure

CAS No. : 137339-65-2

Size Price Stock Quantity
10 mM * 1 mL in Water USD 1470 In-stock
Estimated Time of Arrival: December 31
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 432 In-stock
Estimated Time of Arrival: December 31
10 mg USD 768 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sfllrnpndkyepf is a synthetic thrombin receptor agonist peptide.

In Vitro

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence Sfllrnpndkyepf. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. Sfllrnpndkyepf, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. Sfllrnpndkyepf, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. Sfllrnpndkyepf is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3].

Molecular Weight

1739.92

Formula

C₈₁H₁₁₈N₂₀O₂₃

CAS No.

137339-65-2

SMILES

[SFLLRNPNDKYEPF]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (57.47 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (28.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5747 mL 2.8737 mL 5.7474 mL
5 mM 0.1149 mL 0.5747 mL 1.1495 mL
10 mM 0.0575 mL 0.2874 mL 0.5747 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.22%

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Keywords:

SfllrnpndkyepfThrombinInhibitorinhibitorinhibit

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Sfllrnpndkyepf
Cat. No.:
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