F2 Antibody
(Synonyms: Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); Coagulation factor II; DCP; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain. )F2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to F2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human
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Formulation:
Supplied in A synthesized peptide derived from human Prothrombin.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50 |
Product Details
F2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to F2.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 76 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 70 kDa
A synthesized peptide derived from human Prothrombin aa400-462/622.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in A synthesized peptide derived from human Prothrombin.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)
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Subcellular Localization
Secreted, extracellular space
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Expression
Tissue_specificity:Expressed by the liver and secreted in plasma -
Subunit
Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin. Interacts (thrombin) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (thrombin) with iripin-3, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:33732248). Interacts (thrombin) with Anopheles albimanus salivary thrombin inhibitor anophelin; the interaction results in thrombin inhibition (PubMed:23223529). Interacts (thrombin) with Anopheles gambiae salivary thrombin inhibitor anophelin; the interaction results in thrombin inhibition (PubMed:28592490). Interacts (thrombin) with Amblyomma variegatum variegin; the interaction results in thrombin inhibition (PubMed:22053189). Interacts (thrombin) with Xenopsylla cheopis salivary thrombin inhibitor XC-42 (PubMed:34688666). Interacts (thrombin) with Xenopsylla cheopis salivary thrombin inhibitor XC-43 (PubMed:34688666)
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SwissProt ID
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Synonyms
Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); Coagulation factor II; DCP; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain.
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