2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. F2 Antibody

F2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to F2.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

F2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to F2.
Host

Rabbit
Clonality

Monoclonal,Recombinant
Molecular Weight
Predicted band size: 70 kDa;
Observed band size: 76 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Prothrombin aa400-462/622.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Purity affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in A synthesized peptide derived from human Prothrombin.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)
Subcellular Localization：Secreted, extracellular space
Expression：
Tissue_specificity:Expressed by the liver and secreted in plasma
Subunit：Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin. Interacts (thrombin) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (thrombin) with iripin-3, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:33732248). Interacts (thrombin) with Anopheles albimanus salivary thrombin inhibitor anophelin; the interaction results in thrombin inhibition (PubMed:23223529). Interacts (thrombin) with Anopheles gambiae salivary thrombin inhibitor anophelin; the interaction results in thrombin inhibition (PubMed:28592490). Interacts (thrombin) with Amblyomma variegatum variegin; the interaction results in thrombin inhibition (PubMed:22053189). Interacts (thrombin) with Xenopsylla cheopis salivary thrombin inhibitor XC-42 (PubMed:34688666). Interacts (thrombin) with Xenopsylla cheopis salivary thrombin inhibitor XC-43 (PubMed:34688666)
Database

Entrez Gene: 2147 Human

SwissProt: P00734 Human

OMIM: 613679 Human

Synonyms
Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); Coagulation factor II; DCP; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain.
Documentation
User Guide for Antibodies (1077 KB)

F2 Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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F2 Antibody
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HY-P81243
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