Thrombin inhibitor 11
Based on 1 Customer Validation
Thrombin inhibitor 11 is an orally active, competitive and selective α-Thrombin inhibitor, with a Ki value of 65 nM against h-αThrombin and a Ki value of 10.3 nM against rat-derived α-thrombin. Thrombin inhibitor 11 can be used for the research of thrombotic diseases.
For research use only. We do not sell to patients.
- Purity: 99.77%
- Formula: C32H39ClN4O4
- Molecular Weight:579.13
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Thrombin inhibitor 11 (Compound 46) inhibits h-αThrombin (Ki = 65 nM) and rat α-Thrombin (Ki = 10.3 nM)[1].
Thrombin inhibitor 11 (8 h) exhibits high proteolytic stability in simulated gastric fluid and simulated intestinal fluid[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Bioavailability |
|---|---|---|---|---|
| Rat[1] | 10 mg/kg | p.o. | 400 nM | 18.4 % |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar Han (male, 10-11 weeks old, 250-350 g)[1]
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Dosage:1 mg/kg; 10 mg/kg
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Administration:i.v.; single dose; p.o.; single dose
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Result:Reached a maximal plasma concentration (Cmax) of 400 nM after oral administration.
Achieved an absolute oral bioavailability of 18.4%.
Chemical Information
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Appearance Solid
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Molecular Weight 579.13
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Formula C32H39ClN4O4
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Color White to off-white
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SMILES
ClC1=CC=C(C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](C4)CCC3)=O)=O)CC/C=C/CCCCNC4=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (172.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7267 mL | 8.6336 mL | 17.2673 mL | 43.1682 mL |
| 5 mM | 0.3453 mL | 1.7267 mL | 3.4535 mL | 8.6336 mL | |
| 10 mM | 0.1727 mL | 0.8634 mL | 1.7267 mL | 4.3168 mL | |
| 15 mM | 0.1151 mL | 0.5756 mL | 1.1512 mL | 2.8779 mL | |
| 20 mM | 0.0863 mL | 0.4317 mL | 0.8634 mL | 2.1584 mL | |
| 25 mM | 0.0691 mL | 0.3453 mL | 0.6907 mL | 1.7267 mL | |
| 30 mM | 0.0576 mL | 0.2878 mL | 0.5756 mL | 1.4389 mL | |
| 40 mM | 0.0432 mL | 0.2158 mL | 0.4317 mL | 1.0792 mL | |
| 50 mM | 0.0345 mL | 0.1727 mL | 0.3453 mL | 0.8634 mL | |
| 60 mM | 0.0288 mL | 0.1439 mL | 0.2878 mL | 0.7195 mL | |
| 80 mM | 0.0216 mL | 0.1079 mL | 0.2158 mL | 0.5396 mL | |
| 100 mM | 0.0173 mL | 0.0863 mL | 0.1727 mL | 0.4317 mL |
Thrombin inhibitor 11 Related Classifications
HY-162109 Related Classifications
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