Serpin B6 Protein, Human (sf9, His)
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (sf9, His) is the recombinant human-derived Serpin B6 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (sf9, His) is the recombinant human-derived Serpin B6 protein, expressed by Sf9 insect cells , with N-His labeled tag.
Background
The Serpin B6 protein emerges as a potential regulator, potentially playing a role in the modulation of serine proteinases found in the brain or extravasated from the blood. It functions as an inhibitor of cathepsin G, kallikrein-8, and thrombin, indicating its involvement in the regulation of these proteases. Notably, Serpin B6 may play a crucial role in the inner ear, contributing to the protection against the leakage of lysosomal content during stress. Loss of this protective function is implicated in cell death and sensorineural hearing loss, highlighting the significance of Serpin B6 in maintaining inner ear homeostasis. Additionally, the protein forms a complex with the monomeric form of beta-tryptase, further expanding its potential interactions and roles in cellular processes.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-His
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Accession
P35237 (D2-P376)
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Molecular Construction
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N-term
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His
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Serpin B6 (D2-P376)
Accession # P35237 -
C-term
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Protein Length
Full Length
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Synonyms
SERPINB6; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 6; Prev. PI6; PI-6; Prev. DFNB91; Protease Inhibitor 6 (Placental Thrombin Inhibitor); PTI; Deafness, Autosomal Recessive 91; CAP; Peptidase Inhibitor 6; Cytoplasmic Antiproteinase; MSTP057
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AA Sequence
DVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
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Predicted Molecular Mass
44.9 kDa
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Molecular Weight
Approximately 43 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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