PAR4 antagonist 1
PAR4 antagonist 1 (Compound 48) is a protease activated receptor 4 (PAR4) antagonist with an IC50 of 1.8 nM. PAR4 antagonist 1 has an IC50 of 2 nM against γ-thrombin-activated PAR4 in platelet-rich plasma (PRP). PAR4 antagonist 1 can be used in antithrombotic research.
For research use only. We do not sell to patients.
- CAS No.: 2173201-65-3
- Formula: C26H21FN6O4S
- Molecular Weight:532.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PAR4 1.8 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
2.1 nM
Compound: 48
|
Inhibition of alpha-thrombin induced human Platelet rich plasma aggregation incubated for 5 min followed by alpha-thrombin stimulation by Spectra max microplate reader analysis
Inhibition of alpha-thrombin induced human Platelet rich plasma aggregation incubated for 5 min followed by alpha-thrombin stimulation by Spectra max microplate reader analysis
|
[PMID: 38385264] |
Chemical Information
-
CAS No. 2173201-65-3
-
Molecular Weight 532.55
-
Formula C26H21FN6O4S
-
SMILES
COC1=NC2=CC(C)=CC(C3=NC4=C(C5=C(C(F)=C4)O[C@H](C5)COC(NC6=CN=C(N=C6)C)=O)S3)=C2N=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz