GPRP (Synonyms: Gly-Pro-Arg-Pro; Pefa 6003)

Name: GPRP
Brand: MedChemExpress
SKU: HY-P0074
Rating: 5.0 (3 reviews)

Cat. No.: HY-P0074 Purity: 99.77%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GPRP (Gly-Pro-Arg-Pro; Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction between fibrinogen and the platelet membrane glycoprotein Ⅱb/IIIa complex (glycoprotein IIb/IIIa receptor). GPRP increases the level of free thrombin in activated platelet-rich plasma by reducing the adsorption of thrombin onto fibrin. GPRP inhibits platelet aggregation and prolongs the thrombin-initiated clotting time in plasma. GPRP is applicable for research related to thrombosis and thrombotic diseases.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GPRP Chemical Structure

CAS No. : 67869-62-9

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5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of GPRP:

GPRP acetate In-stock

3 Publications Citing Use of MCE GPRP

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Biological Activity
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Description

In Vitro

GPRP (2-4 mM; 60 seconds) enhances the generation of free thrombin in human platelet-rich plasma. Specifically, 2 mM GPRP increases the thrombin peak level to 400 nM and the area under the curve to 1090 nM·min; 4 mM GPRP raises the thrombin peak level to 450 nM and the area under the curve to 1245 nM·min^[1].
GPRP binds reversibly to the D fragment of human fibrinogen with an association constant of 5×10⁴ M^-1, but does not bind to the E fragment of human fibrinogen^[2].
GPRP prolongs the clotting time of citrated human plasma induced by thrombin, with a relative inhibitory potency of 100%^[2].
GPRP dose-dependently inhibits the reaggregation of human fibrin monomers, with a relative fibrin polymerization inhibitory efficacy of 100%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

425.48

Formula

C₁₈H₃₁N₇O₅

CAS No.

67869-62-9

Appearance

Solid

Color

White to off-white

Sequence

Gly-Pro-Arg-Pro

Sequence Shortening

GPRP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (235.03 mM; Need ultrasonic)

DMSO : 66.67 mg/mL (156.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3503 mL	11.7514 mL	23.5029 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (278 KB) SDS (254 KB)

COA (253 KB) RP-HPLC (252 KB) MS (188 KB) Elemental Analysis Report (113 KB)

Handling Instructions (2659 KB)

References

[1]. Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. [Content Brief]

[2]. Hsieh KH, et al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar;24(3):322-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.3503 mL	11.7514 mL	23.5029 mL	58.7572 mL
	5 mM	0.4701 mL	2.3503 mL	4.7006 mL	11.7514 mL
	10 mM	0.2350 mL	1.1751 mL	2.3503 mL	5.8757 mL
	15 mM	0.1567 mL	0.7834 mL	1.5669 mL	3.9171 mL
	20 mM	0.1175 mL	0.5876 mL	1.1751 mL	2.9379 mL
	25 mM	0.0940 mL	0.4701 mL	0.9401 mL	2.3503 mL
	30 mM	0.0783 mL	0.3917 mL	0.7834 mL	1.9586 mL
	40 mM	0.0588 mL	0.2938 mL	0.5876 mL	1.4689 mL
	50 mM	0.0470 mL	0.2350 mL	0.4701 mL	1.1751 mL
	60 mM	0.0392 mL	0.1959 mL	0.3917 mL	0.9793 mL
	80 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7345 mL
	100 mM	0.0235 mL	0.1175 mL	0.2350 mL	0.5876 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

GPRP Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GPRP (Synonyms: Gly-Pro-Arg-Pro; Pefa 6003)

Customer Review

Other Forms of GPRP:

GPRP Related Antibodies

3 Publications Citing Use of MCE GPRP

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

GPRP Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

GPRP Related Classifications

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Customer Review

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