2. Cytoskeleton
  3. Integrin
  4. GPRP acetate

GPRP acetate  (Synonyms: Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate)

Cat. No.: HY-P0074A Purity: 99.92%
COA Handling Instructions

Molarity Calculator

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GPRP acetate Chemical Structure

GPRP acetate Chemical Structure

CAS No. : 157009-81-9

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1 mg USD 42 In-stock
5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 720 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GPRP acetate:

GPRP acetate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE GPRP acetate

View All Integrin Isoform Specific Products:

View All Isoforms
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3].

In Vitro

GPRP acetate (0, 2 and 4 mM) increases free thrombin generation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPRP acetate Related Antibodies
In Vivo

GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis[3]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result: Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.
Molecular Weight

485.53

Formula

C20H35N7O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Pro-Arg-Pro
Sequence Shortening

GPRP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (257.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0596 mL 10.2980 mL 20.5961 mL
5 mM 0.4119 mL 2.0596 mL 4.1192 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (205.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

COA (250 KB) HNMR (290 KB) LCMS (87 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0596 mL 10.2980 mL 20.5960 mL 51.4901 mL
5 mM 0.4119 mL 2.0596 mL 4.1192 mL 10.2980 mL
10 mM 0.2060 mL 1.0298 mL 2.0596 mL 5.1490 mL
15 mM 0.1373 mL 0.6865 mL 1.3731 mL 3.4327 mL
20 mM 0.1030 mL 0.5149 mL 1.0298 mL 2.5745 mL
25 mM 0.0824 mL 0.4119 mL 0.8238 mL 2.0596 mL
30 mM 0.0687 mL 0.3433 mL 0.6865 mL 1.7163 mL
40 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.2873 mL
50 mM 0.0412 mL 0.2060 mL 0.4119 mL 1.0298 mL
60 mM 0.0343 mL 0.1716 mL 0.3433 mL 0.8582 mL
80 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.6436 mL
100 mM 0.0206 mL 0.1030 mL 0.2060 mL 0.5149 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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GPRP acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPRP157009-81-9Gly-Pro-Arg-ProPefa 6003Pefa6003Pefa-6003IntegrinFibrinpolymerizationfibrinogenplateletglycoproteinIIb/IIIaGPIIb/IIIaInhibitorinhibitorinhibit

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