2. Metabolic Enzyme/Protease Anti-infection
  3. Endogenous Metabolite Bacterial
  4. N-Acetyltaurine

N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes.

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N-Acetyltaurine

N-Acetyltaurine Chemical Structure

CAS No. : 19213-70-8

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Other Forms of N-Acetyltaurine:

N-Acetyltaurine Related Antibodies

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Description

N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes[1][2][3][4][5].

In Vitro

N‑acetyltaurine (100 μM; 1 h) is hydrolyzed into taurine and acetate by recombinant mouse PTER protein, and shows high hydrolytic activity in HEK293T cells overexpressing PTER but no activity in PTER‑KO HEK293T cells[2].
N‑acetyltaurine is synthesized from taurine and acetate in mouse renal cortex homogenate and in primary human skeletal muscle cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetyltaurine Related Antibodies
In Vivo

N-acetyltaurine (1-50 mg/kg; i.p.; daily; 7 days) administered intraperitoneally to DIO male mice reduces body weight and food intake in a dose-dependent manner[2].
N-acetyltaurine (15-50 mg/kg; i.p.; daily; 7 days) reduces body weight and food intake in healthy chow-fed male mice[2].
N-acetyltaurine (15 mg/kg; i.p.; daily; 7 days) reduces body weight and food intake in DIO male mice[2].
N-acetyltaurine (15 mg/kg; i.p.; daily; 7 days) reduces body weight and food intake in DIO male Mc4r KO mice, indicating the effects of N-acetyltaurine do not require functional MC4R receptors[2].
N-acetyltaurine (50-500 mg/kg; p.o.; daily; 7 days) administered orally to DIO male mice reduces body weight and food intake in a dose-dependent manner, with significant effects observed at doses of 150 mg/kg and 500 mg/kg daily for 7 days, and achieves measurable plasma levels following oral gavage[2].
N-Acetyltaurine levels were increased in response to Triacetin (HY-B0896)-induced hyperacetatemia[5].
N-Acetyltaurine levels were significantly increased in response to endogenous hyperacetatemia from Streptozotocin (HY-13753)-induced diabetes[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 26-28 weeks old, diet-induced obese)[2]
Dosage: 1 mg/kg; 5 mg/kg; 15 mg/kg; 50 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change and food intake in a dose-dependent manner at 15 mg/kg and 50 mg/kg compared with vehicle.
Animal Model: C57BL/6J (male, 19-21 weeks old, diet-induced obese)[2]
Dosage: 15 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change and food intake significantly compared with vehicle.
Animal Model: C57BL/6J (male, 13 weeks old, chow-fed)[2]
Dosage: 15 mg/kg; 50 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change nd food intake significantly at 50 mg/kg compared with vehicle.
Animal Model: C57BL/6J (male, 16 weeks old, diet-induced obese)[2]
Dosage: 15 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight gain and food intake significantly.
Animal Model: C57BL/6J (male, 3 months old, diet-induced obese)[2]
Dosage: 50 mg/kg; 150 mg/kg; 500 mg/kg
Administration: p.o.; daily; 7 days
Result: Increased plasma N-acetyltaurine levels dose-dependently.
Reduced body weight gain and food intake significantly at 150 mg/kg and 500 mg/kg.
Animal Model: Mc4r KO (C57BL/6J background, male, 3-4 months old, diet-induced obese)[2]
Dosage: 15 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change and food intake significantly compared with vehicle, similar to effects observed in wild-type DIO mice.
Molecular Weight

167.18

Formula

C4H9NO4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C)NCCS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (1046.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 175 mg/mL (1046.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9816 mL 29.9079 mL 59.8158 mL
5 mM 1.1963 mL 5.9816 mL 11.9632 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

SDS (394 KB)

COA (246 KB) HNMR (246 KB) RP-HPLC (253 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.9816 mL 29.9079 mL 59.8158 mL 149.5394 mL
5 mM 1.1963 mL 5.9816 mL 11.9632 mL 29.9079 mL
10 mM 0.5982 mL 2.9908 mL 5.9816 mL 14.9539 mL
15 mM 0.3988 mL 1.9939 mL 3.9877 mL 9.9693 mL
20 mM 0.2991 mL 1.4954 mL 2.9908 mL 7.4770 mL
25 mM 0.2393 mL 1.1963 mL 2.3926 mL 5.9816 mL
30 mM 0.1994 mL 0.9969 mL 1.9939 mL 4.9846 mL
40 mM 0.1495 mL 0.7477 mL 1.4954 mL 3.7385 mL
50 mM 0.1196 mL 0.5982 mL 1.1963 mL 2.9908 mL
60 mM 0.0997 mL 0.4985 mL 0.9969 mL 2.4923 mL
80 mM 0.0748 mL 0.3738 mL 0.7477 mL 1.8692 mL
100 mM 0.0598 mL 0.2991 mL 0.5982 mL 1.4954 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-Acetyltaurine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyltaurine19213-70-8Endogenous MetaboliteBacterialGDF15orb spiderswild-type micesulfoacetaldehyde acetyltransferaseN-acetyltaurine amidaseDelftia acidovorans NATacetateGFRAL receptorstaurine dehydrogenasetaurineInhibitorinhibitorinhibit

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