Hypotaurine
Based on 3 publication(s) in Google Scholar
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 300-84-5
- Formula: C2H7NO2S
- Molecular Weight:109.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Hypotaurine
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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RT-PCR
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WB
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IF
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan[1]. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 300-84-5
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Appearance Solid
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Molecular Weight 109.15
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Formula C2H7NO2S
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Color White to off-white
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SMILES
NCCS(O)=O
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Synonyms
2-Aminoethanesulfinic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
J Adv Res
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging. [Abstract]2024 May 7:S2090-1232(24)00183-8. PMID: 38718895 -
Front Cell Dev Biol
2021 Apr 15:9:631163. PMID: 33937232
Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163. [Abstract]
The proliferative rate of CRC cell lines after treatment with Taurine (10 mM) and/or Hypotaurine (10 mM).
Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163. [Abstract]
The cellular migratory effects of Taurine (10 mM) and/or Hypotaurine (10 mM) in CRC cells were evaluated by wound-healing assay and quantified.
Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163. [Abstract]
The effects of Taurine and/or Hypotaurine (10 mM) on EMT markers in CRC cells were measured by qRT-PCR.
Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163. [Abstract]
The effects of Taurine and/or Hypotaurine (10 mM) on the phosphorylation (denoted p-) status of ERK and RSK were assessed with western blotting analysis.
Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163. [Abstract]
Quantification of cleaved caspase-3+ area per × 200 field and dual CK+ and Ki-67+ cells per × 400 field treated with Hypotaurine (200 mg/kg).
Solvent & Solubility
H2O : 125 mg/mL (1145.21 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (916.17 mM); Clear solution; Need ultrasonic
Protocol
Rats: A radiant heat source is focused on the middle part of the rat’s tail. The time interval from the onset of the stimulus until the tail flick response is measured using a tail flick unit. The intensity of the radiant heat is adjusted to give a tail flick latency of 4–5 s before the administration of hypotaurine or saline. In the absence of a response, the stimulus is terminated after 15 s (cutoff) to prevent tissue damage. The effects of hypotaurine (100, 200, 400, and 600 μg) on thermal nociception are assessed repeatedly for 120 min post-injection[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Green TR, et al. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073(1):91-7. https://www.ncbi.nlm.nih.gov/pubmed/1846756 [Content Brief]
[2]. Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7(12):15200-14. [Content Brief]
[3]. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 9.1617 mL | 45.8085 mL | 91.6170 mL | 229.0426 mL |
| 5 mM | 1.8323 mL | 9.1617 mL | 18.3234 mL | 45.8085 mL | |
| 10 mM | 0.9162 mL | 4.5809 mL | 9.1617 mL | 22.9043 mL | |
| 15 mM | 0.6108 mL | 3.0539 mL | 6.1078 mL | 15.2695 mL | |
| 20 mM | 0.4581 mL | 2.2904 mL | 4.5809 mL | 11.4521 mL | |
| 25 mM | 0.3665 mL | 1.8323 mL | 3.6647 mL | 9.1617 mL | |
| 30 mM | 0.3054 mL | 1.5270 mL | 3.0539 mL | 7.6348 mL | |
| 40 mM | 0.2290 mL | 1.1452 mL | 2.2904 mL | 5.7261 mL | |
| 50 mM | 0.1832 mL | 0.9162 mL | 1.8323 mL | 4.5809 mL | |
| 60 mM | 0.1527 mL | 0.7635 mL | 1.5270 mL | 3.8174 mL | |
| 80 mM | 0.1145 mL | 0.5726 mL | 1.1452 mL | 2.8630 mL | |
| 100 mM | 0.0916 mL | 0.4581 mL | 0.9162 mL | 2.2904 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hypotaurine Related Classifications
HY-100803 Related Classifications
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