2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Hypotaurine

Hypotaurine  (Synonyms: 2-Aminoethanesulfinic acid)

Cat. No.: HY-100803 Purity: 99.98%
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Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant.

For research use only. We do not sell to patients.

CAS No. : 300-84-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
Solid
50 mg In-stock
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200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Hypotaurine:

Hypotaurine Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
Cell Migration/Invasion Assay
RT-PCR
WB
IF

    Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163.  [Abstract]

    The proliferative rate of CRC cell lines after treatment with Taurine (10 mM) and/or Hypotaurine (10 mM).

    Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163.  [Abstract]

    The cellular migratory effects of Taurine (10 mM) and/or Hypotaurine (10 mM) in CRC cells were evaluated by wound-healing assay and quantified.

    Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163.  [Abstract]

    The effects of Taurine and/or Hypotaurine (10 mM) on EMT markers in CRC cells were measured by qRT-PCR.

    Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163.  [Abstract]

    The effects of Taurine and/or Hypotaurine (10 mM) on the phosphorylation (denoted p-) status of ERK and RSK were assessed with western blotting analysis.

    Hypotaurine purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Apr 15:9:631163.  [Abstract]

    Quantification of cleaved caspase-3+ area per × 200 field and dual CK+ and Ki-67+ cells per × 400 field treated with Hypotaurine (200 mg/kg).

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan[1]. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Hypotaurine Related Antibodies
    In Vivo

    Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    109.15

    Formula

    C2H7NO2S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCS(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 125 mg/mL (1145.21 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 9.1617 mL 45.8085 mL 91.6170 mL
    5 mM 1.8323 mL 9.1617 mL 18.3234 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (916.17 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.98%

    SDS (393 KB)

    COA (243 KB) HNMR (223 KB) RP-HPLC (205 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References
    Animal Administration
    [3]

    Rats: A radiant heat source is focused on the middle part of the rat’s tail. The time interval from the onset of the stimulus until the tail flick response is measured using a tail flick unit. The intensity of the radiant heat is adjusted to give a tail flick latency of 4–5 s before the administration of hypotaurine or saline. In the absence of a response, the stimulus is terminated after 15 s (cutoff) to prevent tissue damage. The effects of hypotaurine (100, 200, 400, and 600 μg) on thermal nociception are assessed repeatedly for 120 min post-injection[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 9.1617 mL 45.8085 mL 91.6170 mL 229.0426 mL
    5 mM 1.8323 mL 9.1617 mL 18.3234 mL 45.8085 mL
    10 mM 0.9162 mL 4.5809 mL 9.1617 mL 22.9043 mL
    15 mM 0.6108 mL 3.0539 mL 6.1078 mL 15.2695 mL
    20 mM 0.4581 mL 2.2904 mL 4.5809 mL 11.4521 mL
    25 mM 0.3665 mL 1.8323 mL 3.6647 mL 9.1617 mL
    30 mM 0.3054 mL 1.5270 mL 3.0539 mL 7.6348 mL
    40 mM 0.2290 mL 1.1452 mL 2.2904 mL 5.7261 mL
    50 mM 0.1832 mL 0.9162 mL 1.8323 mL 4.5809 mL
    60 mM 0.1527 mL 0.7635 mL 1.5270 mL 3.8174 mL
    80 mM 0.1145 mL 0.5726 mL 1.1452 mL 2.8630 mL
    100 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2904 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Hypotaurine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Hypotaurine300-84-52-Aminoethanesulfinic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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