19213-70-8
Chemical Structure
N-Acetyltaurine
- CAS No.: 19213-70-8
- Formula:C4H9NO4S
- Molecular Weight:167.18
IUPAC Name: (4-acrylamidophenyl)mercury(II) chloride
InChIKey: CXJAAWRLVGAKDV-UHFFFAOYSA-N
SMILES: O=C(C)NCCS(=O)(O)=O
Biological Activity: N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes[1][2][3][4][5].
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N-Acetyltaurine | 98.71% | N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes. | ||||||||||||||||||||
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N-Acetyltaurine (Standard) | 99.33% | N-Acetyltaurine (Standard) is the analytical standard of N-Acetyltaurine (HY-W587486). This product is intended for research and analytical applications. N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes. | ||||||||||||||||||||
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- [1]. Mayer J, et al. N-acetyltaurine dissimilated via taurine by Delftia acidovorans NAT. Arch Microbiol. 2006;186(1):61-67. [Content Brief]
- [2]. Wei W, et al. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Nature. 2024;633(8028):182-188. [Content Brief]
- [3]. Miyazaki T, et al. N-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises. Metabolites. 2021;11(8):522. Published 2021 Aug 6. [Content Brief]
- [4]. Luginbühl M, et al. N-Acetyltaurine as a novel urinary ethanol marker in a drinking study. Anal Bioanal Chem. 2016;408(26):7529-7536. [Content Brief]
- [5]. Mao Q, et al. Characterization of Urinary N-Acetyltaurine as a Biomarker of Hyperacetatemia in Mice. Metabolites. 2024;14(6):322. Published 2024 Jun 7. [Content Brief]
