1. Neuronal Signaling
  2. Amyloid-β
  3. ALZ-801

ALZ-801 

Cat. No.: HY-117259
Handling Instructions

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.

For research use only. We do not sell to patients.

ALZ-801 Chemical Structure

ALZ-801 Chemical Structure

CAS No. : 1034190-08-3

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Description

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease[2].

IC50 & Target

β-amyloid[1]

In Vivo

ALZ-801 (oral administration; 172 mg/kg; single dose) exhibits mean AUCt values of 58,758 and 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

238.30

Formula

C₈H₁₈N₂O₄S

CAS No.

1034190-08-3

SMILES

O=S(CCCNC([[email protected]@H](N)C(C)C)=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ALZ-801ALZ801ALZ 801Amyloid-ββ-amyloid peptideAbetaβ-amyloidTramiprosateAlzheimerdiseaseInhibitorinhibitorinhibit

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ALZ-801
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HY-117259
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