GFR alpha-2
GFRα-2 (GFRA2, also called NRR-2 or RETL2) is the preferred co-receptor for neurturin, although it also binds GDNF with lower affinity. Like other family members it is tethered to the membrane by a GPI anchor and must recruit RET, or alternatively signal through NCAM, to transmit signals. GFRA2 is expressed in parasympathetic and enteric neurons, pancreas and testis. Gfra2-deficient mice display reduced innervation of exocrine glands, smaller salivary and lacrimal glands, mucosal secretory defects and altered intestinal motility, yet remain viable. Recombinant GFRα-2 supports neurturin binding assays, parasympathetic neuron cultures and studies of RET-independent signaling.
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GFR alpha-2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
