GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His)

GFRA2/GDNFR-α-2 protein acts as a receptor for neurotrophic factors and promotes NRTN-induced autophosphorylation and RET receptor activation. It also mediates GDNF signaling through the RET tyrosine kinase receptor. GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA2/GDNFR-alpha-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His) is 420 a.a., with molecular weight of ~75 kDa.

GFRA2/GDNFR-alpha-2 Protein serves as the receptor for neurturin, facilitating the NRTN-induced autophosphorylation and activation of the RET receptor. Additionally, it plays a role in mediating GDNF signaling through the RET tyrosine kinase receptor. Notably, GFRA2/GDNFR-alpha-2 is involved in the NRTN-induced phosphorylation of STAT3 at 'Ser-727,' highlighting its participation in signaling pathways associated with cell responses. These interactions underscore the significance of GFRA2 in transducing signals that regulate cellular processes and contribute to the intricate network of signaling events involved in neuronal development and maintenance.

Mouse

HEK293

C-His

O08842/NP_032141.2 (S22-S441)

14586  [NCBI]

Approximately 75 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.