Gfra2 - glial cell line derived neurotrophic factor family receptor alpha 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14586

Summary

The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and Neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Gfra2 Products (3)

mRNA Protein Name
NM_001302094.1 NP_001289023.1 GDNF family receptor alpha-2 isoform 2
NM_001302095.1 NP_001289024.1 GDNF family receptor alpha-2 isoform 3 precursor
NM_008115.3 NP_032141.2 GDNF family receptor alpha-2 isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
9576965 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
11069590 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDNF family receptor alpha-2

  • GDNF receptor beta

  • GDNFR-alpha-2

  • GDNFR-beta

  • GFR alpha 2

  • NRTNR-alpha

  • NTNR-alpha

  • TGF-beta-related neurotrophic factor receptor 2

  • neurturin receptor alpha

Recombinant Gfra2 Proteins

Cat. No. Product Name Accession Purity
HY-P76950 GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His) O08842-1/NP_032141.2 (S22-S441) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS27452 Gfra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05387 GFRA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20935 Gfra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfra2 NCBI NCBI:2675