GFRA2 - GDNF family receptor alpha 2 Gene

Homo sapiens

Also known as NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA

Gene ID: 2675 | Gene type: protein coding

About GFRA2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:21,690,398-21,812,345 (from NCBI)

This gene has 8 transcripts (splice variants), 278 orthologues and 4 paralogues. Broad expression in spleen (RPKM 6.1), thyroid (RPKM 5.3) and 19 other tissues.

Summary

Glial cell line-derived neurotrophic factor (GDNF) and Neurturin (NTN) are two structurally related, potent Neurotrophic Factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GFRA2 Products(3)

mRNA	Protein	Name
NM_001165038.2	NP_001158510.1	GDNF family receptor alpha-2 isoform b precursor
NM_001165039.2	NP_001158511.1	GDNF family receptor alpha-2 isoform c precursor
NM_001495.5	NP_001486.4	GDNF family receptor alpha-2 isoform a preproprotein

GFRA2 Protein Structure

GDNF

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

GDNF family receptor alpha-2

GDNF receptor beta

Recombinant GFRA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70192	GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His)	O00451 (S22-S441)	≥95%

Related Diseases

Diseases

Alias

Bladder Leiomyoma

Leiomyoma Of The Urinary Bladder

Retinal Degeneration

Degeneration Of Retina

Malignant Granular Cell Myoblastoma

Malignant Granular Cell Tumor	Granular Cell Tumor, Malignant
Malignant Granular Cell Neoplasm

Bladder Benign Neoplasm

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05387	GFRA2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GFRA2	MGD	MGI:1195462
Canis familiaris	GFRA2	VGNC	VGNC:41190
Bos taurus	GFRA2	VGNC	VGNC:29333
Felis catus	GFRA2	VGNC	VGNC:62530
Macaca mulatta	GFRA2	VGNC	VGNC:72918
Rattus norvegicus	GFRA2	RGD	RGD:61809
Others	GFRA2	NCBI

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