Neurturin
Neurturin (NRTN) is a member of the GDNF (glial cell line-derived neurotrophic factor) family of ligands, structurally defined by a cystine-knot motif and processing of a pre-pro-precursor into a secreted disulfide-linked homodimer. Neurturin binds the co-receptor GFRα2 with high specificity, and the complex engages the receptor tyrosine kinase RET, triggering autophosphorylation that activates MAPK, PI3K-AKT and Src-family cascades. Functionally, neurturin is a potent survival and trophic factor for midbrain dopaminergic neurons, sympathetic and sensory neurons of the peripheral nervous system, enteric neurons and renal epithelial branching. This neurotrophic profile made neurturin a leading candidate for Parkinson's disease gene therapy: AAV2-neurturin (CERE-120/Liaterminol taregene) delivered to the striatum aimed to restore dopaminergic function, with trials showing safety but mixed efficacy. Neurturin-GFRα2 signaling is likewise essential for parasympathetic innervation of salivary glands and cutaneous mechanoreceptors, and neurturin contributes to spermatogonial stem cell maintenance and neuropathic pain modulation.
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Neurturin Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
