2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family
  6. GFR-alpha-1

GFR-alpha-1

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Cat. No. Product Name / Synonyms Species Source
  • HY-P76360
    GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His)

    GDNF family receptor alpha-1; GFR-alpha-1; GDNFRA; TRNR1

    		Mouse HEK293
    GFRA1/GDNFR-alpha-1, a receptor for GDNF, mediates GDNF-induced autophosphorylation and activation of the RET receptor. It interacts with RET and forms a complex with disulfide-linked GDNF dimer, and interacts with SORL1. The SORL1-GFRA1 interaction results in GFRA1 internalization without degradation. GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) is 401 a.a., with molecular weight of 55-65 KDa.
  • HY-P76948
    GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc)

    GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1

    		Rat HEK293
    GFRA1/GDNFR-α-1 protein is a receptor for GDNF and critically mediates GDNF-induced autophosphorylation and RET receptor activation. Presumably, two GDNFR-α-1 molecules form a complex with disulfide-linked GDNF, two RET molecules, and SORL1, suggesting the existence of a coordinated signaling mechanism. GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc) is 445 a.a., with molecular weight of ~85 kDa.
  • HY-P76949
    GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His)

    GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1

    		Rat HEK293
    GFRA1/GDNFR-α-1 protein is a receptor for GDNF and critically mediates GDNF-induced autophosphorylation and RET receptor activation. Presumably, two GDNFR-α-1 molecules form a complex with disulfide-linked GDNF, two RET molecules, and SORL1, suggesting the existence of a coordinated signaling mechanism. GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His) is the recombinant rat-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His) is 421 a.a., with molecular weight of 58-65 kDa.
  • HY-P70384
    GFRA1/GDNFR-alpha-1 Protein, Human (410a.a, HEK293, His)

    rHuGDNF family receptor alpha-1/GFRA1, His; GFRα1; GDNF Family Receptor Alpha-1; GDNF Receptor Alpha-1; GDNFR-Alpha-1; GFR-Alpha-1; RET Ligand 1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRA1; GDNFRA; RETL1; TRNR1

    		Human HEK293
    The GFRA1/GDNFR-alpha-1 Protein serves as a receptor for GDNF, facilitating GDNF-induced autophosphorylation and activation of the RET receptor. In a complex, two molecules of GDNFR-alpha-1 are believed to associate with the disulfide-linked GDNF dimer and two molecules of RET. It interacts with RET and SORL1, either alone or in a complex with GDNF, leading to GFRA1 internalization without degradation. GFRA1/GDNFR-alpha-1 Protein, Human (410a.a, HEK293, His) is the recombinant human-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GFRA1/GDNFR-alpha-1 Protein, Human (410a.a, HEK293, His) is 405 a.a., with molecular weight of ~60.0 kDa.
  • HY-P77371
    GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His)

    GDNF family receptor alpha-1; GFR-alpha-1; GDNFRA; TRNR1

    		Canine HEK293
    GFRA1 is a co-receptor that recognizes the GDNF ligand family and is involved in the regulation of proliferation, differentiation and migration of neuronal cells. GFRA1 promotes autophagy through the SRC-AMP-activated protein kinase (AMPK) signaling pathway, thereby contributing to the development of cisplatin-induced chemotherapy resistance to osteosarcoma. GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His) is the recombinant canine-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His) is 405 a.a., with molecular weight of 53-60 kDa.
  • HY-P700449
    GFRAL Protein, Mouse (HEK293, His-Myc)

    GFR alpha-like; GFRAL; GRAL; C6orf144

    		Mouse HEK293
    GFRAL protein, a brainstem-restricted receptor, regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. It binds with GDF15, interacts with RET, and activates MAPK- and AKT- signaling pathways. GFRAL acts as a receptor for GDF15 and mediates cellular signaling through RET, requiring prior GDF15 binding. GFRAL Protein, Mouse (HEK293, His-Myc) is the recombinant mouse-derived GFRAL protein, expressed by HEK293, with C-Myc, N-10*His labeled tag. The total length of GFRAL Protein, Mouse (HEK293, His-Myc) is 330 a.a., with molecular weight of 42.1 kDa.
Cat. No. Product Name Effect Purity