GFR-alpha-1
GFRα-1 (GFRA1) is the GPI-anchored co-receptor that confers high-affinity binding of GDNF and, to a lesser extent, neurturin. Lacking transmembrane and cytoplasmic regions, it presents ligand to the RET receptor tyrosine kinase, which then activates RAS-MAPK and PI3K-AKT survival signaling. GFRA1 is expressed in enteric neuron precursors, kidney, testis and subsets of central and peripheral neurons; Gfra1-null mice phenocopy Ret knockouts, showing aganglionic megacolon and kidney agenesis. Variants near GFRA1 have been associated with Hirschsprung disease. Recombinant GFRα-1 is used to measure GDNF-family ligand binding, in RET co-receptor studies and neutralizing antibody development.
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GFR-alpha-1 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
