GFR-alpha-3
GFRα-3 (GFRA3) is the co-receptor with the strongest preference for artemin among the GDNF-family ligands. It is expressed predominantly in sympathetic ganglia and in nociceptive sensory neurons of dorsal root and trigeminal ganglia, with little presence in the central nervous system. GFRA3/RET signaling supports sympathetic neuron survival and modulates nociceptor responses; Gfra3-knockout mice show attenuated nerve-injury-induced pain behaviors, making the artemin-GFRα3 axis a target of interest for neuropathic pain therapy. GFRA3 has also been proposed as a co-factor in certain cancers. Recombinant GFRα-3 is used for artemin binding studies, pain research models and GDNF-family ligand selectivity characterization.
-
GFR-alpha-3 Recombinant Proteins (4)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
