2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins
  4. TGF-beta Superfamily Neurotrophic Factors Cytokine Receptors
  5. GDNF family
  6. GFR-alpha-3
  7. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc)

GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc)

Cat. No.: HY-P77372
Instrucciones de manejo Technical Support

GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

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  • Descripciòn

Descripciòn

GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
Background

GFRA3/GDNFR-alpha-3 Protein functions as the receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). It plays a crucial role in mediating the autophosphorylation and activation of the RET receptor tyrosine kinase upon stimulation by artemin. Additionally, GFRA3/GDNFR-alpha-3 interacts with SORL1, indicating its involvement in various cellular signaling pathways.
Species

Human
Source

HEK293
Tag

C-hFc;C-His
Accession

O60609-1/NP_001487.2 (D32-W382)
Gene ID
Molecular Construction
N-term
GFRA3 (D321-W382)
Accession # O60609-1/NP_001487.2
hFc-His
C-term
Protein Length

Partial
Synonyms
GDNF family receptor alpha-3; GFR-alpha-3; GFRA3
AA Sequence

DPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPW

Predicted Molecular Mass
67.3 kDa
Peso molecular

Approximately 80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Pureza

≥ 80%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentación
Instrucciones de manejo (2659 KB)

GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc)
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