2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family
  6. GFR-alpha-3
  7. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc)

GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc)

Cat. No.: HY-P77372
Handling Instructions

GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of ~80 kDa.

For research use only. We do not sell to patients.

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Description

GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of ~80 kDa.
Background

GFRA3/GDNFR-alpha-3 Protein functions as the receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). It plays a crucial role in mediating the autophosphorylation and activation of the RET receptor tyrosine kinase upon stimulation by artemin. Additionally, GFRA3/GDNFR-alpha-3 interacts with SORL1, indicating its involvement in various cellular signaling pathways.
Species

Human
Source

HEK293
Tag

C-hFc;C-His
Accession

O60609 (M1-W382)
Gene ID
Molecular Construction
N-term
GFRA3 (M1-W382)
Accession # O60609
hFc-His
C-term
Synonyms
GDNF family receptor alpha-3; GFR-alpha-3; GFRA3
Molecular Weight

Approximately 80 kDa
Purity

Greater than 80% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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