2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins
  4. TGF-beta Superfamily Neurotrophic Factors Cytokine Receptors
  5. GDNF family
  6. GFR-alpha-3
  7. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc)

GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc labeled tag.

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Descripciòn

GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc labeled tag.
Background

The GFRA3/GDNFR-alpha-3 Protein serves as a receptor for the glial cell line-derived neurotrophic factor, artemin, facilitating artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. The protein interacts with SORL1, suggesting potential involvement in signaling cascades associated with neurotrophic responses.
Species

Mouse
Source

HEK293
Tag

C-hFc
Accession

O35118 (N29-R379)
Gene ID
Molecular Construction
N-term
GFRA3/GDNFR-alpha-3 (N29-R379)
Accession # O35118
hFc
C-term
Protein Length

Full Length of Mature Protein (with Propeptide)
Synonyms
GDNF family receptor alpha-3; GFR-alpha-3
AA Sequence

NSLATENRFVNSCTQARKKCEANPACKAAYQHLGSCTSSLSRPLPLEESAMSADCLEAAEQLRNSSLIDCRCHRRMKHQATCLDIYWTVHPARSLGDYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLHDKCDRLRKAYGEACSGIRCQRHLCLAQLRSFFEKAAESHAQGLLLCPCAPEDAGCGERRRNTIAPSCALPSVTPNCLDLRSFCRADPLCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFISKVNTTVALSCTCRGSGNLQDECEQLERSFSQNPCLVEAIAAKMRFHRQLFSQDWADSTFSVVQQQNSNPALRLQPR

Predicted Molecular Mass
66.2 kDa
Peso molecular

Approximately 70 kDa,based on SDS-PAGE under reducing conditions.
Glycosylation
Yes
Pureza

≥ 80%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentación
Instrucciones de manejo (2659 KB)

GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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