Gfra3 - glial cell line derived neurotrophic factor family receptor alpha 3 Gene

Also Known as GFRalpha3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14587

Summary

This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand Artemin to the RET receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015]

Gfra3 Products (1)

mRNA Protein Name
NM_010280.4 NP_034410.3 GDNF family receptor alpha-3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables axon guidance receptor activity IMP
IMP: Inferred from mutant phenotype
12160745 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9452475 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
10482239 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
10482239 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
10482239 MGI
acts upstream of or within sympathetic nervous system development IMP
IMP: Inferred from mutant phenotype
10482239 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9452475 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDNF family receptor alpha-3

  • GDNFR-alpha-3

  • GFR alpha-3

Recombinant Gfra3 Proteins

Cat. No. Product Name Accession Purity
HY-P76951 GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) O35118 (N29-R379) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P76952 GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) O35118 (N29-R379) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05388 GFRA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19200 Gfra3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25688 Gfra3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99748 Nadecnemab Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfra3 NCBI NCBI:2676