2. Metabolic Enzyme/Protease
  3. Neprilysin
  4. Sacubitril sodium

Sacubitril sodium  (Synonyms: AHU-377 sodium)

Cat. No.: HY-15407B Purity: 99.95%
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Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19.

For research use only. We do not sell to patients.

CAS No. : 149690-05-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Sacubitril sodium:

Sacubitril sodium Related Antibodies

Top Publications Citing Use of Products

    Sacubitril sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812.

    N2a-APP cells were treated with Diosmin (Dio; 80 μM), FICZ (250 nM), L-KN (3 μM) or Indole-3-acetamide (I3C; 10 μM) with or without SR1 (2 μM) or Sacubitril (Sac; 1 μM) for 24 h, the supernatant was collected and the Aβ42 levels were determined by ELISA.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19[1][2][3].

    In Vitro

    Sacubitril sodium increases neprylisin-degraded peptides, such as natriuretic peptides (NPs), peptide natriuretic atrial (ANP) and peptide natriuretic brain (BNP)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sacubitril sodium Related Antibodies
    In Vivo

    In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)[1].
    Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    433.47

    Formula

    C24H28NNaO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(CCC(O[Na])=O)N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@@H](C)C(OCC)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (115.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3070 mL 11.5348 mL 23.0696 mL
    5 mM 0.4614 mL 2.3070 mL 4.6139 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.95%

    SDS (393 KB)

    COA (249 KB) HNMR (261 KB) LCMS (93 KB) OR (203 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3070 mL 11.5348 mL 23.0696 mL 57.6741 mL
    5 mM 0.4614 mL 2.3070 mL 4.6139 mL 11.5348 mL
    10 mM 0.2307 mL 1.1535 mL 2.3070 mL 5.7674 mL
    15 mM 0.1538 mL 0.7690 mL 1.5380 mL 3.8449 mL
    20 mM 0.1153 mL 0.5767 mL 1.1535 mL 2.8837 mL
    25 mM 0.0923 mL 0.4614 mL 0.9228 mL 2.3070 mL
    30 mM 0.0769 mL 0.3845 mL 0.7690 mL 1.9225 mL
    40 mM 0.0577 mL 0.2884 mL 0.5767 mL 1.4419 mL
    50 mM 0.0461 mL 0.2307 mL 0.4614 mL 1.1535 mL
    60 mM 0.0384 mL 0.1922 mL 0.3845 mL 0.9612 mL
    80 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7209 mL
    100 mM 0.0231 mL 0.1153 mL 0.2307 mL 0.5767 mL
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    Sacubitril sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sacubitril149690-05-1AHU-377AHU377AHU 377NeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10COVID-19neutral endopeptidasenatriuretic peptideantihypertensiveheart failureInhibitorinhibitorinhibit

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