Sacubitrilat-d4
Based on 1 Customer Validation
Sacubitrilat-d4 is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.28%
- Formula: C22H21D4NO5
- Molecular Weight:387.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 149709-44-4
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Appearance Solid
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Molecular Weight 387.46
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Formula C22H21D4NO5
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Color White to off-white
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SMILES
OC([C@H](C)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC(C=C1)=CC=C1C2=CC=CC=C2)=O
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Synonyms
Desethyl Sacubitril-d4; LBQ-657-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (258.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909. [Content Brief]
[3]. Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72(8):917-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5809 mL | 12.9046 mL | 25.8091 mL | 64.5228 mL |
| 5 mM | 0.5162 mL | 2.5809 mL | 5.1618 mL | 12.9046 mL | |
| 10 mM | 0.2581 mL | 1.2905 mL | 2.5809 mL | 6.4523 mL | |
| 15 mM | 0.1721 mL | 0.8603 mL | 1.7206 mL | 4.3015 mL | |
| 20 mM | 0.1290 mL | 0.6452 mL | 1.2905 mL | 3.2261 mL | |
| 25 mM | 0.1032 mL | 0.5162 mL | 1.0324 mL | 2.5809 mL | |
| 30 mM | 0.0860 mL | 0.4302 mL | 0.8603 mL | 2.1508 mL | |
| 40 mM | 0.0645 mL | 0.3226 mL | 0.6452 mL | 1.6131 mL | |
| 50 mM | 0.0516 mL | 0.2581 mL | 0.5162 mL | 1.2905 mL | |
| 60 mM | 0.0430 mL | 0.2151 mL | 0.4302 mL | 1.0754 mL | |
| 80 mM | 0.0323 mL | 0.1613 mL | 0.3226 mL | 0.8065 mL | |
| 100 mM | 0.0258 mL | 0.1290 mL | 0.2581 mL | 0.6452 mL |
Sacubitrilat-d4 Related Classifications
HY-17620S Related Classifications
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