OSMR beta Protein, Mouse (HEK293, His)

The OSMR beta Protein, in partnership with IL31RA, constitutes the IL31 receptor, binding IL31 to activate STAT3, and potentially STAT1 and STAT5. OSMR beta also transduces OSM-specific signaling. It forms a heterodimer with IL6ST, creating the type II OSM receptor, and another heterodimer with IL31RA for the IL31 receptor. OSMR beta Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSMR beta protein, expressed by HEK293, with C-His labeled tag. The total length of OSMR beta Protein, Mouse (HEK293, His) is 714 a.a., with molecular weight of 115-140 kDa.

The OSMR beta Protein associates with IL31RA to form the IL31 receptor. It binds IL31, triggering the activation of STAT3, and possibly STAT1 and STAT5 (By similarity). Additionally, OSMR beta is capable of transducing OSM-specific signaling events (By similarity). It forms a heterodimer with IL6ST, constituting the type II OSM receptor, and another heterodimer with IL31RA to shape the IL31 receptor.

Mouse

HEK293

C-His

O70458 (E24-M737)

18414  [NCBI]

115-140 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.