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OSMR beta Protein, Human (HEK293, His)

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The OSMR beta protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor with IL-23R. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. OSMR beta Protein, Human (712a.a, HEK293, His) is the recombinant human-derived OSMR beta protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

The OSMR beta protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor with IL-23R. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. OSMR beta Protein, Human (712a.a, HEK293, His) is the recombinant human-derived OSMR beta protein, expressed by HEK293 , with C-6*His labeled tag.

Background

The IL-23R protein plays a critical role in immune response by forming the interleukin-23 receptor through its association with IL12RB1. This receptor binds to IL23 and triggers the activation of T-cells, NK cells, and potentially certain macrophage/myeloid cells via the Jak-Stat signaling cascade. IL23 is involved in both innate and adaptive immunity and likely contributes to the acute response to infection in peripheral tissues. Additionally, IL23 is implicated in autoimmune inflammatory diseases and has been shown to be important in tumorigenesis. When IL12RB1 is present, IL-23R forms a heterodimer that acts as the IL-23 receptor and interacts with JAK2 to activate STAT3.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-6*His
  • Accession

    Q99650 (E28-S739)

  • Gene ID
    9180  [NCBI]
  • Molecular Construction
    • N-term
    • OSMR beta (E28-S739)
      Accession # Q99650
    • 6*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    OSMR; IL-31 Receptor Subunit Beta; Oncostatin M Receptor; IL-31R Subunit Beta; OSMRB; IL-31R-Beta; Oncostatin-M-Specific Receptor Subunit Beta; IL-31RB; OSMRbeta; Oncostatin-M Specific Receptor Beta Subunit; Interleukin-31 Receptor Subunit Beta; PLCA1

  • AA Sequence

    ERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSS

  • Predicted Molecular Mass

    82 kDa

  • Molecular Weight

    Approximately 130 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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